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Prof Dr med dent Hendrik Terheyden is head physician at the Department of Oral and Maxillofacial Surgery, Helios Hospital in Kassel, Germany. Hendrik Terheyden studied dentistry from 1983 to 1989 at the University of Kiel. In 1989, he was a staff physician for the Navy in Flensburg. From 1989-1992 he studied human medicine at the University of Kiel. In 1993 he became a specialist in oral surgery and in 1997 a specialist in oral and maxillofacial surgery with the additional title of plastic surgery (1999). In 1999 he completed his PhD (Habilitation) at the University of Kiel. He received the Wassmund Prize of the German Society for Oral and Maxillofacial Surgery (DGMKG). In 2004, he became an adjunct professor at Kiel University. From 2009 to 2012, he was president of the German Society for Implantology, and from 2017 to 2019, he was Chairman of the Oral and Maxillofacial Surgery Working Group of the German Society for Oral and Maxillofacial Surgery (DGZMK). Since 2006, Prof Terheyden has been section editor of the International Journal of Oral & Maxillofacial Surgery, and since 2012 he has been editor in chief of the International Journal of Implant Dentistry. Since 2021, he has served on the board of the Working Group of Senior Hospitalists of the German Society for Oral and Maxillofacial Surgery.
1st Edition 2022 Book Hardcover, 21 x 28 cm, 408 pages, 1383 illus Language: English Categories: Implantology, Oral/Maxillofacial Surgery, Oral Surgery Stock No.: 7707 ISBN 978-1-78698-113-4 QP Deutschland
Series: Cell-to-Cell Communication, Band 6 1. Auflage 2019 DVD 2 DVDs inkl. detailliertem Booklet im Hardcover Language: German Category: Implantology ISBN 978-3-86867-404-0 QP Deutschland
Series: Cell-to-Cell Communication, Volume 6 1st Edition 2019 DVD 2 DVDs and a detailed booklet in hardcover; PAL/NTSC; 15 min Language: English Category: Implantology Stock No.: 7621 ISBN 978-1-78698-021-2 QP Deutschland
Series: Cell-to-Cell Communication, Band 5 1. Auflage 2017 DVD 2 DVDs inkl. detailliertem Booklet im Hardcover Language: German Category: Implantology ISBN 978-3-86867-341-8 QP Deutschland
Series: Cell-to-Cell Communication, Volume 5 1st Edition 2016 DVD 2 DVDs and a detailed booklet in hardcover; PAL/NTSC; 15 min Language: English Category: Implantology Stock No.: 7481 ISBN 978-1-78698-003-8 QP Deutschland
Series: Cell-to-Cell Communication, Volume 3 1st Edition 2015 DVD 2 DVDs and a detailed booklet in a hardcover; NTSC/PAL Language: English Categories: Human Medicine, Periodontics Stock No.: 7392 ISBN 978-1-85097-280-8 QP Deutschland
Series: ITI Treatment Guide Series, Band 07 1. Auflage 2014 Book Hardcover, 232 pages, 600 illus colored Language: German Category: Implantology ISBN 978-3-86867-235-0 QP Deutschland
Series: Cell-to-Cell Communication, Volume 2 2nd Edition 2013 DVD 2 DVDs and a detailed booklet in a hardcover; NTSC/PAL Language: English Categories: Human Medicine, Periodontics Stock No.: 7236 ISBN 978-1-85097-243-3 QP Deutschland
Details make perfection24. Oct 2024 — 26. Oct 2024MiCo - Milano Convention Centre, Milano, Italy
Speakers: Bilal Al-Nawas, Gil Alcoforado, Federico Hernández Alfaro, Sofia Aroca, Wael Att, Gustavo Avila-Ortiz, Kathrin Becker, Anne Benhamou, Juan Blanco Carrión, Dieter Bosshardt, Daniel Buser, Francesco Cairo, Paolo Casentini, Raffaele Cavalcanti, Tali Chackartchi, Renato Cocconi, Luca Cordaro, Luca De Stavola, Nuno Sousa Dias, Egon Euwe, Vincent Fehmer, Alberto Fonzar, Helena Francisco, Lukas Fürhauser, German O. Gallucci, Oscar Gonzalez-Martin, Dominik Groß, Robert Haas, Alexis Ioannidis, Simon Storgård Jensen, Ronald Jung, France Lambert, Luca Landi, Georg Mailath-Pokorny jun., Silvia Masiero, Iva Milinkovic, Carlo Monaco, Jose Nart, José M. Navarro, Katja Nelson, Manuel Nienkemper, David Nisand, Michael Payer, Sergio Piano, Bjarni E. Pjetursson, Sven Reich, Isabella Rocchietta, Giuseppe Romeo, Irena Sailer, Mariano Sanz, Ignacio Sanz Martín, Frank Schwarz, Shakeel Shahdad, Massimo Simion, Ralf Smeets, Benedikt Spies, Bogna Stawarczyk, Martina Stefanini, Hendrik Terheyden, Tiziano Testori, Daniel Thoma, Ana Torres Moneu, Piero Venezia, Lukas Waltenberger, Hom-Lay Wang, Stefan Wolfart, Giovanni Zucchelli, Otto Zuhr
European Association for Osseintegration (EAO)
EAO Digital Days
Implantology: Beyond your expectations12. Oct 2021 — 14. Oct 2021online
Speakers: Enrico Agliardi, Alessandro Agnini, Andrea Mastrorosa Agnini, Mauricio Araujo, Goran Benic, Juan Blanco Carrión, Daniel Buser, Raffaele Cavalcanti, Tali Chackartchi, Luca Cordaro, Jan Cosyn, Holger Essig, Vincent Fehmer, Stefan Fickl, Alberto Fonzar, Helena Francisco, German O. Gallucci, Ramin Gomez-Meda, Oscar Gonzalez-Martin, Robert Haas, Arndt Happe, Alexis Ioannidis, Ronald Jung, Niklaus P. Lang, Tomas Linkevičius, Iva Milinkovic, Sven Mühlemann, Katja Nelson, Sergio Piano, Michael A. Pikos, Bjarni E. Pjetursson, Marc Quirynen, Franck Renouard, Isabella Rocchietta, Dennis Rohner, Irena Sailer, Henning Schliephake, Shakeel Shahdad, Massimo Simion, Ali Tahmaseb, Hendrik Terheyden, Jochen Tunkel, Stefan Vandeweghe, Piero Venezia, Stijn Vervaeke, Martin Wanendeya, Georg Watzek, Giovanni Zucchelli
European Association for Osseintegration (EAO)
This author's journal articles
Deutsche Zahnärztliche Zeitschrift, 1/2023
NachrufPages 59-62, Language: GermanTerheyden, Hendrik / Wiltfang, Jörg
Gemeinsamer Nachruf ehemaliger Kollegen und Schüler
Gemeinsamer Nachruf ehemaliger Kollegen und Schüler
Kompetenz, Empathie und nie en¬dender Forschungsdrang – diese Attribute kennzeichneten ein beeindruckendes und erfolgreiches Leben für die Zahn-, Mund- und Kieferheilkunde in Deutschland und weit darüber hinaus: Am 24. Februar 2021 ist unser verehrter Lehrer, Kollege und Freund Prof. Dr. med. Dr. med. dent. Bodo Hoffmeister nach kurzer Krankheit mit 72 Jahren leider viel zu früh von uns gegangen.
Osteoklasten wurden lange für mesenchymale Knochenzellen gehalten. Aber neue Kenntnisse aus der Entwicklungsbiologie hinsichtlich der molekularen Steuerung der Zelldifferenzierung und der Immunmodulation des Knochenabbaus weisen die Osteoklasten klar als Mitglieder des Immunsystems aus. Osteoklasten sind für viele zahnärztliche Therapien wie die geordnete Zahneruption und kiefer-orthopädische Zahnbewegung, den Umbau eines Knochentransplantates oder die Osseointegration eines Zahnimplantates unerlässlich. Die Bedeutung der Osteoklasten bei der oralen Immunabwehr wird insbesondere bei Dysfunktionen der Osteoklasten deutlich, so beispielsweise bei der medikamenten-assoziierten Kiefernekrose. Die Immunmodulation der Osteoklastogenese kann zu foudroyanten Verläufen bis hin zur eitrigen Entzündung führen, wofür die entzündliche Wurzelresorption und die Periimplantitis klinische Beispiele sind. Die Aufgabe des Zahnarztes in diesen Situationen ist die Minderung der Osteoklastogenese durch Reduktion der mikrobiellen Antigenbelastung durch endodontische Behandlung bzw. Kontrolle des Biofilmes. Die marginale Parodontitis kann der Osteoimmunologie als Modell zur Erforschung der entzündlichen Knochenresorptionen dienen. Hiervon profitieren im Gegenzug auch andere Fachbereiche wie z. B. die Rheumatologie.
Keywords: Osteoklasten, Zelldifferenzierung, Osteoimmunologie, Wurzelresorption, Kiefernekrose, Zytokine
This complementary article was prepared by Bernd Stadlinger, Søren Jepsen and Hendrik Terheyden and presents an overview of the content of the 6th volume of the "Cell-to-Cell Communication" series. The 6th volume of the series entitled "Peri-implantitis and its prevention" was prepared by a collaborative team of authors - Tord Berglundh, Søren Jepsen, Bernd Stadlinger, Hendrik Terheyden - and an advisory board. This computer-animated scientific film was launched at the EuroPerio meeting in Amsterdam in June 2018, providing a novel way to visualize the complex processes of peri-implant inflammation. It visualizes the biological background of the development and progression of peri-implantitis and highlights the importance of the microbiome and host immune defense. In addition, a perspective article has recently been published in the leading implant journal Clinical Oral Implants Research (Berglundh et. al. 2019). It is hoped that this complementary article will bring the film to the attention of the many ITI Fellows and Members who enjoy reading Forum Implantologicum. Please look for the Q reader at the end of the article and enjoy this captivating film.
Anhand der beiden Parameter Infraokklusion und Implantatüberleben aus Literaturdaten werden in der vorliegenden Arbeit Empfehlungen zur Indikation und zum Zeitpunkt von Zahnimplantaten bei Kindern und Jugendlichen erarbeitet. Bei einer Implantation bei Kindern unter 12 Jahren ist im Schnitt mit ca. 14 bis 17 mm Infraokklusion (Maximum: 20-24 mm) und einem Implantatüberleben von 72 % zu rechnen. Bei Adoleszenten (12-18 Jahre) beträgt die Infraokklusion etwa 3 mm (Maximum: 8 mm) und die Implantatprognose 93 %. Bei jungen Erwachsenen (18-31 Jahre) wurde eine Infraokklusion anhand von Wachstumsstudien von 1,7 mm (Maximum: 6 mm) beobachtet bei einer Implantatprognose von 97,4 %. In Studien zur Frontzahnversorgung liegt die Implantatprognose für ältere Erwachsene eher noch höher, aber auch hier kann es zu Infraokklusionen von im Schnitt 0,3 mm und im Einzelfall über 1 mm kommen. Daher werden Implantate nicht zum Einzelzahnersatz in der Zahnreihe bei Kindern empfohlen, hier kommt eine Implantatversorgung eher bei schweren Hypodontien oder Anodontien infrage. Bei Adoleszenten sollte die tradierte harte Grenze des 18. Lebensjahrs eher einer differenzierten Bewertung weichen und ersetzt werden durch das Abwarten des pubertären Wachstumsspurts. Die sicher auftretende Infraokklusion sollte aber therapeutisch antizipiert und wie die etwas reduzierte Implantatprognose den Patienten und Eltern mitgeteilt werden. Auch nach dem 18. Lebensjahr kommt es zu Infraokklusionen, worüber der Patient aufgeklärt werden sollten.
Keywords: Infraokklusion, Kinder, Adoleszenten, Implantatüberleben, Ankylose, Wachstum, Kieferentwicklung
Objectives: Reconstruction of bony defects can be done by free flaps. Donor site morbidity and misfit of the shape are limiting factors. The concept of using the patient as bioreactor solved many problems. The aim of the study was to evaluate if the great omentum is a capable anatomical site for prefabrication.
Methods: In each of 30 adult male New Zealand white rabbits (4.0kg) 2 blocks of biomaterial were implanted in the great omentum with a central vascular pedicle in a cavity of the scaffold. The following five groups were created according to the biomaterial: (1) Bio-Oss® Block, (2) Bio-Oss® Block + rhBMP-2, (3) Bio-Oss® Block + rhBMP-2 + VEGF-165 (4) Bio-Oss® Block + autologous bone, (5) Bio-Oss® Block + autologous bone + rhBMP-2. CT examinations were performed after the implantation and 2, 4, 6 and 10 weeks later to define the bone density. The animals were sacrificed at 10 weeks postsurgery after intraperitoneal injection of fluorochromes and the specimens were collected for histological, immunohistochemical and histomorphometric analysis.
Results: First analyses could show that the great omentum has advantage among other sites previously described with a long vascular pedicle, less postoperative functional impairment and more flexibility. The central blood vessel in the center of the scaffold resembles the natural anatomy of the mandible and other bones with a marrow cavity and enhances the ossification. The bone density increases particularly with the use of BMP-2 and VEGF-165 and has the highest values with additional use of autologous bone (HU: average between 483 (BioOss-Block alone) and 1054 (+ autologous bone with BMP-2). The floureszenz staining shows ossification also with BMP alone. Also the toluidine blue and HE staining shows ossifcation and development of new vessels in the scafold. There are indications that the efficacy of the dosage could be enhanced by addition of VEGF-165.
Conclusions: We could demonstrate for the first time that the great omentum is a capable new anatomical site for prefabrication. It can be used as a bioreactor in vivo for prefabrication tissue-engineered bone. Prefabrication in the great omentum may go from bench to bedside and will show effectiveness in mandibular reconstruction.
Keywords: prefabrication, omentum majus, reconstruction, bmp, vegf
The International Journal of Oral & Maxillofacial Implants, 4/2013
DOI: 10.11607/jomi.2594, PubMed ID (PMID): 23869355Pages 982-988, Language: EnglishWarnke, Patrick H. / Voss, Eske / Russo, Paul A. J. / Stephens, Sebastien / Kleine, Michael / Terheyden, Hendrik / Liu, Qin
Purpose: Artificial materials such as dental implants are at risk of bacterial contamination in the oral cavity. Human beta defensins (HBDs), small cationic antimicrobial peptides that exert a broad-spectrum antibacterial function at epithelial surfaces and within some mesenchymal tissues, could probably help to reduce such contamination. HBDs also have protective immunomodulatory effects and have been reported to promote bone remodeling. The aim of this study, therefore, was to investigate the influence of recombinant HBD-2 on the proliferation and survival of cells in culture.
Materials and Methods: Human mesenchymal stem cells (hMSCs), human osteoblasts, human keratinocytes (control), and the HeLa cancer cell line (control) were incubated with recombinant HBD-2 (1, 5, 10, or 20 µg/mL). Cell proliferation and cytotoxicity were evaluated via a water-soluble tetrazolium salt (WST-1) and lactate dehydrogenase assays, respectively.
Results: HBD-2 was not toxic in any tested concentration to hMSCs, osteoblasts, keratinocytes, or HeLa cells. Furthermore, proliferation of hMSCs and osteoblasts increased after treatment with HBD-2 at all tested concentrations, and keratinocyte proliferation increased when treated at 20 µg/mL. In contrast, HeLa cancer cells were not affected by HBD-2 as tested.
Conclusions: HBD-2 is not only biocompatible but also promotes proliferation of hMSCs, osteoblasts, and keratinocytes in culture. Further investigation of HBD-2 functional surface coating of artificial materials is recommended.
Keywords: antimicrobial peptides, biocompatibility, human beta defensins, human mesenchymal stem cells, human primary osteoblasts, implant dentistry