Introduction: The process of reproducing the final color of a rehabilitation is dependent on several factors: the characteristics of the ceramic system used, the thickness of the ceramic, type of ceramic, substrate and cement used. Objectives: To evaluate in vitro the color changes caused by different cementing materials. Materials and Methods: Lithium disilicate ceramic disks A2 color, with thicknesses of 0.5 mm were used (n = 40). For the substrate, composite resin discs with a thickness of 1mm were produced. The ceramic samples were cemented to the composite resin discs with different cements. The data corresponding to the color analysis were obtained with reflection spectrophotometry. The color differences between each sample were recorded with the L * a * b * system of CIELab. Results: There were no statistically significant differences between groups. The RelyX Veneer B0.5 cement corresponds to the group that presents a higher value of Delta E (4.1942) and the cement RelyX Veneer A3 presents a lower value of Delta E (3,4400). Discussion: All cements used had a Delta E value greater than 1.7, which means that all will cause a variation in the final color of the rehabilitation. Conclusions: The fact that the cements do not show statistically significant differences does not imply that these differences are not clinically perceptible. Clinical Implications: The optical properties of the cements are as important as those of the ceramic, and the aesthetics of the ceramic restoration depends on the type of cement used. Keywords: ceramics, color, resin cements, veneers, oral rehabilitation, aesthetics