Knowledge of dental anatomy is important for successful root canal treatment. A clinician is required to have insights into the morphology of a tooth, regarding its shape, form and structure, before commencing treatment. This report describes the treatment of two cases of radix entomolaris (one with bilateral occurrence) and one very rare case of radix paramolaris in an Indian dental school. Keywords: endodontic treatment, prevalence, radix entomolaris, radix paramolaris