This tribute article to Professor Barry J. Sessle summarizes the 6 presentations delivered at the July 1, 2008 symposium at the University of Toronto. The symposium honored 3 "giants" in orofacial neuroscience, Professors B.J. Sessle, J.P. Lund, and A.G. Hannam. The 6 presentations paying tribute to Sessle spanned the period from the early phase of his career up to some of his most recent studies with colleagues in Asia, Europe, and Australia as well as Canada. The studies have included those providing an improved understanding of the cortical control of sensory inputs in pain perception (presented by R. Dubner) and in the control of mastication and swallowing, as well as brainstem mechanisms of orofacial pain (K. Iwata, G. Murray). His current activities in his laboratory and in Denmark are also highlighted (L. Avivi-Arber, P. Svensson). The potential transfer of basic research discoveries toward drug development in pain control that stem from some of his research is also described (B. Cairns). The final section of the paper includes a commentary from Professor Sessle. Keywords: experimental pain, hypertonic saline, jaw muscles, jaw movement, motor cortex, sensorimotor