This case report describes the digital and clinical workflow of a guided endodontic access approach in a mandibular central incisor with pulp canal calcification (PCC). The access to the remaining pulp space was planned virtually using cone beam computed tomography (CBCT) and the Sicat Endo software (Sicat, Bonn, Germany). Sicat produced the corresponding Accessguide after matching a digitized cast model and the virtual treatment plan. The clinical access was prepared using a carbide bur with a diameter of 1.2 mm. After the root canal was localized successfully, it was disinfected chemomechanically, dried, and obturated using a warm vertical compaction technique. Keywords: calcification, CBCT, guided endodontics, root canal treatment, Sicat Endo