The application of modern software algorithms allow for volumetrically accurate fusion of relevant image data, which may be used for planning purposes and for intra-operative guidance in maxillofacial surgery and related specialties. This study evaluates the feasibility and accuracy of different fusion modes and the application of image fusion for image guided surgery (IGS). Within the study, the IGS system VectorVision (BrainLAB, Heimstetten, Germany) was used. The platform currently supports the fusion of the following imaging methods: CT, MRI, Angio-MRI, PET, Sonography, SPECT, Fluoro- Radiography. The most frequently performed fusion was CT in bone windowing with CT in soft tissue windowing in 82.8% of all cases followed by CT/MRI, CT/Angio-MRI and MRI/Angio-MRI. Increasing significance gains the usage of PET data. The fusion of relevant image data, which can now be performed fully automatically, improves the planning and the realization of especially complex procedures in maxillofacial surgery. Keywords: computer tomography, magnetic resonance imaging, positron emissions tomography, sonography, image guided surgery, fusion, imaging