Objective: Describe how advancements in digital technologies and material's science provide additional restorative alternatives and material combinations for single and multiple unit implant-supported restorations, such those incorporating the clinical use of nitride coated titanium bases (TiN) in combination with the 2-piece, CAD/CAM, screw-retained, zirconia-ceramic, hybrid implant-supported restoration concept. 
Materials and methods: Two partially edentulous patients with missing teeth in the maxillary esthetic zone were treated with a novel technical and restorative concept using the 2-piece CAD/CAM screw-retained zirconia-ceramic hybrid-abutment crown concept bonded to nitride coated titanium bases. 
Clinical outcomes: Biologic outcomes showed that tissues were maintained healthy with the patients showing an adequate oral hygiene level, no detectable plaque present upon probing and no bleeding on probing. Esthetic evaluation demonstrated an excellent esthetic outcome and peri-implant soft-tissue integration with adjacent natural teeth and pontic tissue areas, together with post-treatment stability of the gingival zenith position. None of the two patients showed technical complications such screw loosening or porcelain chipping/fracture. Radiographic evaluation reveals a precise fit between TiN bases and the implant connecting interfaces, no marginal bone loss and a stable implant osseointegration. The principal advantages of incorporating nitride coated titanium bases (TiN) in implant supported restorations rely on the favorable esthetic outcomes, improved technical, mechanical, and biological aspects, as well as the physicochemical characteristics of TiN hard thin film coatings and their positive impact on titanium biocompatibility. 
Conclusions: The short term promising clinical outcomes of the 2-piece CAD/CAM screw-retained, zirconia ceramic hybrid abutment crown concept bonded to nitride coated titanium bases, would indicate the potential clinical benefits of the described restorative alternative. However, additional in vitro investigations and randomized clinical trials are needed to validate these initial observations, especially those evaluating the 2-piece CAD/CAM screw-retained, zirconia ceramic hybrid abutment crown bonded to TiN bases when compared to the conventional 2-piece hybrid design as well as stock/custom, metal/zirconia/lithium disilicate, screw/cemented implant supported restorations.