Molar-Incisor Hypomineralization (MIH) is a qualitative developmental defect of the enamel that affects one or more permanent first molars, with or without incisor involvement. This condition often requires esthetic treatment, and therapeutic approaches may vary considerably. The purpose of this case report is to describe a step-by-step clinical protocol for a 20-year-old female patient who presented with dissatisfaction regarding the appearance of her smile due to hypomineralized spots on the maxillary and mandibular anterior teeth. After anamnesis and clinical examination, the diagnosis of MIH was established. Treatment consisted of in-office bleaching followed by resin infiltration for the maxillary teeth, and microabrasion combined with resin infiltration for the mandibular teeth. This sequence of minimally invasive techniques effectively resolved the esthetic alterations caused by MIH, showing satisfactory results that remained stable over one year.