Aim: The aim of the present study is to compare the effectiveness of photobiomodulation therapy versus local 1.2% atorvastatin gel as an adjunct to subgingival instrumentation in the treatment of stage II or III periodontitis.
Materials and methods: In this randomized study, a total of 60 individuals with pocket depths of 4-7mm bilaterally in both sexes (Males and Females) who were 25 years old or older, diagnosed with stage II or III periodontitis were selected. 60 Patients with at least 4 teeth demonstrating pocket depth of ≥ 4–7mm were selected. Exclusion criteria included patients with systemic conditions, smokers, pregnant or lactating women, and those who had received periodontal therapy or antibiotics within the previous six months. Baseline clinical parameters which include full mouth plaque scores, full mouth bleeding scores, probing pocket depth and clinical attachment level were recorded. All the eligible patients underwent supra and subgingival instrumentation. The patients were then randomly divided into two groups: GROUP-A: 30 Patient (120 pocket sites) received photobiomodulation (PBM) therapy with 680 nm for 60 sec(6J/cm2) with 0.1watt power GROUP-B: 30 Patient (120 pocket sites) received 1.2% Atorvastatin (ATV) gel as local drug delivery After the applications of local drug, the treated periodontal pockets were secured with N-butyl-2- cyanoacrylate. Patient were recalled at baseline and after 1 month and 3 months andClinical periodontal parameters were recorded.
Results: On intergroup comparison, this trial demonstrated notable improvements in all clinical parameters at the 3 month interval after Subgingival instrumentation in combination with PBM or LDD. While in intragroup comparison, at 3 months interval, the reductions in probing depth and clinical attachment gain is more significantly evident in group-B (1.2%Atorvastatin gel) compared to group-A (PBM). These findings are consistent with the available literature, which recognizes subgingival instrumentation as an effective non-surgical therapy for periodontitis. Adjunctive treatment modalities are widely investigated to determine whether they can further enhance the clinical outcomes achieved by subgingival instrumentation.
Conclusion: The principal results of this study showed improved periodontal status and a significant improvements in clinical parameters in patients in GROUP-B (1.2% Atorvastatin gel). Within the limitations of the study, it was concluded that both Photobiomodulation and 1.2% Atorvastatin gel can be effectively used as adjuncts to subgingival instrumentation in the treatment of periodontitis.