This clinical report describes the oral rehabilitation of a 7-year-old male diagnosed with hypohidrotic ectodermal dysplasia and anodontia. Our patient exhibited the typical general and cranio-facial features of ED as well as emotional and behavioral problems. The child presents only one conical primary central incisor. The treatment was focused to improve his esthetic needs and oral functions and included the fabrication of removable prostheses and of an acrylic crown on the single tooth existing in his mouth, manufactured by an original simple method. This clinical report demonstrates that the partial and complete removable dentures associated with the acrylic crown can be a reversible and inexpensive method of treatment for young ED patients. Palabras clave: hypohidrotic ectodermal dysplasia, ED, anodontia, prosthodontic treatment, acrylic crown