The inter-relationship between periodontal and endodontic disease has aroused much speculation, confusion and controversy. Pulpal and periodontal problems are responsible for more than 50% of tooth loss today. The prognosis of a true combined lesion is often poor or even hopeless, especially when there is extensive periodontal destruction. The present report describes the use of platelet-rich fibrin (PRF) gel and membrane in combination with a bone graft for treating a tooth with a combined periodonticendodontic lesion. The tooth was endodontically and periodontally treated. Clinical and radiographic follow-up was performed after 6 and 12 months. After 1 year, the absence of a interradicular lesion, pain and swelling along with tooth stability and adequate radiographic bone fill indicated a successful outcome. The success of treating a combined periodontic-endodontic lesion depends on patient cooperation, restorability and economics, which help in acting on treatment decisions. Palabras clave: furcation, Periobone-G, periodontal abscess, periodontic-endodontic lesion, plateletrich fibrin (PRF), regeneration