Desmoplastic ameloblastoma (DA) is a benign but locally invasive variant of the solid/multicystic ameloblastoma (SMA). In the recent World Health Organization classification of odontogenic tumours, DA has been characterised as a variant, with specific clinical, radiographic and histopathological features. A possible 'transitional' form of DA, showing microscopic features of the desmoplastic variant together with areas typical of classic follicular or plexiform ameloblastoma, has been described as a 'hybrid' lesion of ameloblastoma (HLA). A unique case with synchronous emergence of desmoplastic and unicystic ameloblastoma (different growth patterns) in the mandible of a 50-year-old male is reported. Palabras clave: desmoplastic ameloblastoma, growth pattern, mandible, unicystic ameloblastoma