Purpose: To evaluate the influence of fabrication processes on the mechanical properties of denture base resins. Materials and Methods: Flexural strength, fracture toughness, and Vickers hardness were measured on a conventional pack-and-press resin (PRO), a resin for injection molding (CAP), and a CAD/CAM disc (CAD). Results: For maximal flexural strength, PRO (97.31 MPa) was stronger than CAD (87.98 MPa) and CAP (79.35 MPa). CAD displayed hardness similar to PRO and high fracture toughness. Conclusion: CAD/CAM denture base resin mechanical properties result from the evolution of denture base materials, combining highimpact fracture toughness and improved flexural strength and hardness.