Effect of cis-Platinum on bone ingrowth into porous fiber titanium.Mechanical and biochemical correlations

The effect of cis-Platinum on bone ingrowth into the fiber titanium (Ti6Al4V) implants of 36 medicated and 36 control rat tibias was assessed for the amount, composition, and mineralization rate. In this experiment, it was found that cis-Platinum, in therapeutic doses, reduces interfacial strength, inhibits bone ingrowth into the implants and also mineralization of the ingrown bone less than 10 weeks after completed medication.