Purpose: This study evaluated the effect of cutting initiation location and cutting speed on the bond strength between resin cement and feldspathic ceramic. Materials and Methods: Thirty-six blocks (6.4 x 6.4 x 4.8 mm) of ceramic (Vita VM7) were produced. The ceramic surfaces were etched with 10% hydrofluoric acid gel for 60 s and then silanized. Each ceramic block was placed in a silicon mold with the treated surface exposed. A resin cement (Variolink II) was injected into the mold over the treated surface and polymerized. The resin cement-ceramic blocks were divided into two groups according to experimental conditions: a) cutting initiation location - resin cement, ceramic and interface; and b) cutting speed - 10,000, 15,000, and 20,000 rpm. The specimens were sectioned to achieve non-trimmed bar specimens. The microtensile test was performed in a universal testing machine (1 mm/min). The failure modes were examined using an optical light microscope and SEM. Bond strength results were analyzed using one-way ANOVA and Tukey's test (α = 0.05). Results: Significant influences of cutting speed and initiation location on bond strength (p 0.05) were observed. The highest mean was achieved for specimens cut at 15,000 rpm at the interface (15.12 ± 5.36MPa). The lowest means were obtained for specimens cut at the highest cutting speed in resin cement (8.50 ± 3.27MPa), and cut at the lowest cutting speed in ceramic (8.60 ± 2.65MPa). All groups showed mainly mixed failure (75% to 100%). Conclusion: The cutting speed and initiation location are important factors that should be considered during specimen preparation for microtensile bond strength testing, as both may influence the bond strength results. Palabras clave: microtensile bond strength test, cutting speed, ceramic