This case report describes the prosthetic rehabilitation of a patient with ankylosing spondylitis who presented with a malocclusion due to the unfavorable reduction of a mandibular fracture following a traffic accident. The residual malocclusion was successfully corrected with a maxillary removable partial denture and a mandibular onlay removable partial denture. Palabras clave: ankylosing spondylitis, removable partial denture