An effective irrigant delivery system is mandatory for successful endodontic treatment. The endodontic delivery systems developed in recent years rely on various mechanisms and philosophies for cleaning root canal systems. In general, newer endodontic delivery systems lead to improved canal cleanliness in comparison with conventional syringe needle irrigation. Despite the existence of numerous studies aiming to assess these systems, there are currently no evidence-based studies available to correlate their clinical efficacy. As in daily practice, ergonomics is a crucial factor when choosing an endodontic delivery system; it is necessary to determine how these devices are perceived in terms of practicality and ease of use. The present study provides an overview of the endodontic delivery systems currently available. Based on a new ergonomic index, endodontic delivery systems were assessed in terms of volume, working principle and practicality. While effectiveness in cleaning and disinfecting the root canal system is an aspect to consider when selecting a proper irrigation system, this new ergonomic index may help clinicians to select the appropriate endodontic delivery system.