Introduction: The presented poster reports the analysis of a b-TCP-based paste-like bone substitute material for socket preservation and sinus augmentation procedures. Preliminary histological and histomorphometrical results from a multi-centre study are presented. Materials and Methods: Sockets of teeth not worth preserving were augmented according to a standardised study protocol with a b-TCP-based paste-like bone substitute material (Cerasorb Paste, Curasan, Kleinostheim, Germany) and covered with a xenogenic collagen membrane. Further, in cases of reduced dentition and atrophy of the alveolar crest in the upper molar region, sinus floor augmentation was performed to enlarge the amount of local bone previous to insertion of dental implants. After an integration period of three months, implants were inserted in the augmented region simultaneously with bone biopsy extraction for histological and histomorphometrical analysis. Additionally, the inserted implants were investigated with a focus on implant stability and achieved red-white aesthetics. Results: The bone substitute material investigated showed favourable handling and easy application in the sockets of extracted teeth and sinus cavities. A complete and marginal filling of both sockets and sinus cavities could be achieved due to the adhesion and "flow-ability" of the material. Histologic and histomorphometrical results from a preclinical in vivo study in rats showed a biphasic arrangement of the bone substitute material with an inner core and an outer ring, which prevents early ingrowth of connective tissue in the implantation bed. Further, outspreading vessels and no signs of a foreign body reaction to the bone substitute material were obvious. Conclusion: Preliminary clinically results from a multi-centre study investigation of a paste-like b-TCP-based bone substitute material for socket preservation and sinus augmentation showed favourable handling and suitability for augmentation procedures. Further, histological and histomorphometrical in vivo analysis showed good integration of the bone substitute material in the peri-implant tissue, a high rate of vascularisation and no signs of a foreign body reaction. Keywords: b-TCP, bone substitute material, socket preservation, sinus floor augmentation, foreign body reaction