Oral mucosal lesions are a common disease, majority of which are uncertain in origin. Many patients with these mucosal lesions were refractory to available therapies, especially when chronic inflammatory conditions are considered. Treatment of these variants, represent a perplexing therapeutic challenge. Despite numerous existing pharmacotherapies, there are many treatment failures. Pharmacotherapies in mucosal lesions were aimed primarily in reducing the length and severity of symptomatic outbreaks. One promising therapeutic modality emerging for these lesions is non- pharmacotherapy, which has been used with relative success from recent reports. This poster provides an update of current concepts of non- pharmacotherapeutic approaches like cryotherapy, photodynamic therapy and laser therapy in the management of Oral mucosal lesions. Keywords: non pharmacotherapy, cryotherapy, photodynamic therapy, laser therapy