Objectives: To evaluate the outcome of immediately loaded distally cantilevered mandibular full-arch prostheses according to the 'all-on-four' concept supported by implants placed in both fresh extraction and healed sites. Material and methods: A prospective study was conducted in 24 patients with extraction of all remaining mandibular teeth and placement of 4 implants per patient (2 mesial axial and 2 distal tilted) for full-arch mandibular restorations. Implants were inserted in fresh extraction sockets 2.3 ± 1.0 per patient and 1.7 ± 1.0 implants in healed sites. Implants placed in fresh extraction sites (n = 55) were significantly (P 0.01) more deeply inserted than implants (n = 41) placed in healed sites (peri-implant alveolar crest: +1.6 ± 0.8 mm vs +0.6 ± 0.7 mm). Patients received an immediate provisional fixed dental prosthesis and, 3 months later, a definite resin veneered prosthesis with metal framework. At the 12-and 24-month follow-up, patients were evaluated for implants and prosthesis success, for prosthodontic maintenance efforts and patient satisfaction. At both follow-up examinations, peri-implant marginal bone level, implant pocket depth, plaque, bleeding, gingival and calculus indices were evaluated and compared between implants placed in fresh extraction and healed sites. Results: At the 24-month follow-up, no implant failed and all prostheses were stable. There were five fractures of the provisional prosthesis in 5 patients but no fracture of the definite prostheses. For the definite prostheses, 15 acrylic teeth had to be renewed/repaired (in 10 patients) and 18 patients presented the need for the implant-supported prosthesis to be rebased. Peri-implant marginal bone level after 12 and 24 months was -0.18 ± 0.20 mm and -0.40 ± 0.29 mm for all implants (P 0.001) representing bone level differences of 0.35 mm between implants placed in healed and post-extractive sites at both the 1st year (95%-CI:-0.49 to -0.20) and the 2nd year (95%-CI: -0.57 to -0.14) assessment. Plaque (1st year: 1.17 ± 0.48 versus 0.5 ± 0.6; P 0.001; 2nd year: 1.21 ± 0.51 versus 0.55 ± 0.6; P 0.001) and calculus indices (1st year: 0.92 ± 0.28 versus 0.45 ± 0.51; P 0.001; 2nd year: 1.00 ± 0.42 versus 0.5 ± 0.51; P 0.001) were significantly higher for implants placed in fresh extraction than in healed sites. Patients' subjective satisfaction score rating assessed by 5 items was high at the 1- (score: 4.6 ± 0.4) and 2-year evaluation (score: 4.7 ± 0.36). Conclusion: Within the limits of this study, immediately loaded full-arch prostheses can be supported by four implants placed simultaneously into healed and fresh extraction sites. Keywords: edentulous mandible, extraction sites, fixed full arch prostheses, immediate implant placement, immediate loading Conflict of interest statement: Prof Gerald Krennmair was supported by a grant from Camlog Foundation to conduct this research.