Aim: Evaluation of the push-out bond strength of bioceramic root canal sealer (EndoSequence BC) in comparison to a resin-based (AH Plus) sealer and a zinc oxide-eugenol-based (Kerr EWT) sealer. Materials and methods: Sixty-three roots were randomly divided into three groups (n = 21) according to the root canal sealer: group 1, EndoSequence BC; group 2, AH Plus; and group 3, Kerr EWT. Two millimetre-thick horizontal sections from the coronal, middle, and apical thirds of each root were sliced for the push-out bond strength measurement using a universal testing machine after 7, 14 and 30 days. Modes of failure were evaluated using a scanning electron microscope. Statistical analysis was performed using Kruskal-Wallis test and Mann-Whitney U test (P ≤ 0.05). Results: The EndoSequence BC samples showed the highest mean push-out bond strength values after 1 and 4 weeks, followed by AH Plus and Kerr EWT. After 2 weeks, the AH Plus samples showed the highest mean push-out bond strength values followed by EndoSequence BC. Statistically, there was a greater significant difference between the push-out bond strength mean values of the three sealers at each time interval (P 0.001). Conclusion: The time after obturation and the basic composition of the sealer are important factors in determining the bond strength of the sealer to the root canal wall. Keywords: bioceramic, resin-based, zinc oxide-eugenol-based root canal sealer