Aim: The aim of this study was to evaluate the efficacy of crude propolis as a direct pulp-capping agent in both primary and immature permanent teeth. Materials and methods: Eighty-nine asymptomatic molars with pulp exposure were treated by direct pulp capping using Syrian crude propolis. Forty-seven of them were primary molars and forty-two were immature permanent molars. The children were between 5 and 8 years old. The teeth were controlled clinically and radiographically after three observation intervals (1, 6 and 12 months). Coronal restoration has been done with posterior resin composite using light cured glass ionomer cement as a liner. All cases were randomised according to the Consolidated Standards of Reporting Trails (CONSORT). Teeth were evaluated clinically and radiographically, and statistical analyses were performed using the Friedman test. Results: After 12 months, the success rate was 87.23% in primary teeth and 100% in permanent teeth. Conclusion: The Syrian crude propolis seems to be an effective direct pulp-capping agent in immature permanent teeth. Keywords: direct pulp capping, immature permanent teeth, primary teeth, propolis