This report presents six consecutive cases of peri-implantitis associated with residual methacrylate cement. The cases responded to cement removal and disinfection procedures. Six patients, each presenting one methacrylate cementretained implant restoration and showing peri-implant inflammation and bone loss, were treated. All the cases were negative for bleeding on probing after 6 weeks, and this was maintained at 1 year of follow-up from nonsurgical therapy and crown refixation with alternative and resorbable cement. The treatment effectively solved the inflammation and led to complete restoration ad integrum, as evaluated clinically and radiographically, after 1 year.