DOI: 10.11607/prd.1545, PubMed ID (PMID): 23593621Pages 281-287, Language: EnglishOkuda, Kazuhiro / Kawase, Tomoyuki / Nagata, Masaki / Yamamiya, Kanoko / Nakata, Koh / Wolff, Larry F. / Yoshie, HiromasaOne-year data after autologous grafting of infrabony periodontal defects with human cultured periosteum sheets in combination with platelet-rich plasma and hydroxyapatite granules have shown favorable clinical and radiographic results. A 5-year follow-up evaluation of 22 selected patients indicated that treated infrabony defects remained stable. Radiographically, there was an increase in osseous radiopacity and bone trabeculation suggesting further bone maturation. This novel tissue-engineered periodontal treatment approach has resulted in significant clinical improvement, and defects remained stable after 5 years.
