Objective: To determine if there was a difference in hard and soft tissue between northern Chinese and northern Indian adolescents with Angle Class II division 1 malocclusion. Method: A total of 40 Angle Class II division 1 patients, including 20 boys and 20 girls aged 10 to 13 years with no prior treatment, were selected from northern China and northern India, respectively. Overall, 80 cephalometric data were analysed based on two-sample t-test with SPSS software. Results: The Chinese subjects had larger anterior facial height and mandibular plane angle. Analysis of dentoalveolar complex showed that the Chinese subjects had more proclined incisors, protruding upper lips and more upper posterior tooth height than that of the Indian subjects. The length of the maxilla and mandible was larger in the Indian subjects than that of the Chinese subjects, but the length of mandible was not significantly different between the two groups. Conclusion: Compared with the Indian subjects, the Chinese subjects with Class II division 1 malocclusion had less prognathic maxillas, more protruding lips, steeper mandibular plane angles and more proclined maxillary incisors. Within the same gender, the Indian boys had more protruded faces and Indian girls had more protruded maxillas, steeper mandibular plane angles and fuller lips. Keywords: Class II division 1 malocclusion, Chinese adolescents, Indian adolescents, cephalometrics, hard and soft tissue