Pages 203-209, Language: EnglishHarmon, Jennifer B. / Sanders, Anne E. / Wilder, Rebecca S. / Essick, Greg K. / Slade, Gary D. / Hartung, Jane E. / Nackley, Andrea G.Aims: To investigate the relationship between omentin-1 levels and painful temporomandibular disorders (TMD).
Methods: In a case-control design, chronic painful TMD cases (n = 90) and TMD-free controls (n = 54) were selected from participants in the multisite OPPERA study (Orofacial Pain: Prospective Evaluation and Risk Assessment). Painful TMD case status was determined by examination using established Research Diagnostic Criteria for TMD (RDC/TMD). Levels of omentin-1 in stored blood plasma samples were measured by using an enzymelinked immunosorbent assay. Binary logistic regression was used to calculate the odds ratios (ORs) and 95% confidence limits (CLs) for the association between omentin-1 and painful TMD. Models were adjusted for study site, age, sex, and body mass index.
Results: The unadjusted association between omentin-1 and chronic painful TMD was statistically nonsignificant (P = .072). Following adjustment for covariates, odds of TMD pain decreased 36% per standard deviation increase in circulating omentin-1 (adjusted OR = 0.64; 95% CL: 0.43, 0.96; P = .031).
Conclusion: Circulating levels of omentin-1 were significantly lower in painful TMD cases than controls, suggesting that TMD pain is mediated by inflammatory pathways.
Keywords: chronic pain, epidemiology, etiology, inflammation mediators, temporomandibular disorders
