Purpose: To analyze the clinical fit of monolithic zirconia single crowns (MZSCs) in a prospective cohort study. Materials and Methods: A total of 30 posterior teeth were restored with MZSCs. Silicone replicas were made to measure the clinical fit using a stereomicroscope. Measurements were conducted at 17 points per crown at the marginal and occlusal surfaces. Results: The mean clinical fit was 0.104 mm at the crown margin and 0.101 mm at the occlusal surface. Measured distances at the marginal and occlusal surfaces were comparable. Conclusion: MZSCs showed acceptable clinical fit.