Resin cements are the preferred luting media for ceramic restorations, but manufacturers have traditionally made no recommendations concerning the use of dentin bonding agents in the luting process. This in vitro study evaluated the microleakage associated with several luting agents for ceramic inlays. One hundred twenty Class V inlays (occlusal margins in enamel and gingival margins in dentin) were luted in extracted teeth using zinc phosphate cement, two resin cements without a bonding agent, and two resin cements with three dentin bonding agents. This study suggests that the use of a dentin bonding agent with a resin cement will reduce microleakage in cast glass-ceramic restorations.