Purpose: This article provides preliminary clinical results on the Osseotite NT implant, which was developed to simplify surgical procedure and cover an extended range of indications. Placement characteristics of NT and standard Osseotite implants were also compared in an in vitro study. Materials and Methods: The in vitro placement characteristics of NT and standard Osseotite implants of 4.0 mm diameter and 8.5 to 15 mm in length were compared. In addition, a total of 182 NT implants (96 maxillary and 86 mandibular) were placed in 92 patients; of these, 87.9% were placed using a 1-stage technique. The implants were placed in healed sites (43.9%), fresh extraction sockets (37.4%), or recent extraction sites (2 months postextraction) (18.7%). Before restoration, healing times of 3 to 4 months in the mandible and 5 to 6 months in the maxilla were allowed. The entered implant length in the osteotomy site before contacting the bony walls (EILOS) was compared, as well as the number of turns and the time required to seat the implants. Cumulative survival rates (CSRs) were calculated for up to 18 months of follow-up after surgery. Results: The EILOS was between 47.3% and 57.6% of implant length for the NT implants; for the standard implants, it was between 12.0% and 21.2%. With the NT implants, the number of turns and the placement time were reduced by 61% to 64% and 61% to 65%, respectively. In the clinical study, 4 implants failed during the healing period; none failed after prosthesis placement. The CSR was 97.79% for implants placed into fresh or recent extraction sites; in healed sites, the CSR was 98.75%. The cumulative prosthetic success rate was 100%. Discussion: This new implant design is seated with special drills; the drilling sequence requires less time and less torque than that used for standard implants. The low failure rate after prosthetic loading was consistent with that observed for standard Osseotite implants. Conclusion: These preliminary data suggest that the NT implant can be predictable in healed sites and fresh or relatively recent extraction sockets.