Force distribution with natural teeth depends on micromovement induced by the periodontal ligament. The location and cusp inclination of the tooth qualitatively alter the force pattern. Osseointegrated implants do not have micromovement associated with force distribution. Force distribution to the osseointegrated implant interface is completely different than with natural teeth. Alterations in tooth location and cusp inclination are suggested to limit implant overload. Force distribution in splinted natural teeth and osseointegrated prostheses are compared. The mechanism of interface force distribution and the consequences of poor interface fit are interrelated. The differential mobility of splinted natural teeth affects diagnosis and treatment. However, combining natural teeth with an osseointegrated prosthesis requires new design principles. Keywords: differential mobility, force distribution, impact area, interface force distribution, micromovement, micron movement, modulus of elasticity