Purpose: To evaluate the bond strength of resin to zirconia treated with different surface conditioning methods. Materials and Methods: Sintered zirconia was surface treated to create 7 groups. Ceramic liner (L) was fired onto three groups of zirconia and subsequently received the following treatments: hydrofluoric acid etching (L/ HFE), alumina particle abrasion (L/APA), and alumina particle abrasion with hydrofluoric acid etching (L/APAHFE). All three groups were silane treated immediately prior to bonding. Two other zirconia groups received alumina particle abrasion with and without silane coupling (AP-S and AP). Another group underwent selective infiltration etching, in which the specimens received porcelain powder firing, ultrasonic etching with HF for 15 min, then rinsing under running water for 15 min, followed by silane treatment (SIE). The control group was zirconia as-sintered (ZAS). Twenty composite resin cylinders were luted to each group with a resin cement. Each group was divided into two subgroups (n=10) and subjected to 2 storage conditions: 24 h water storage or 21 days with 6000 thermocycles between 5°C and 55°C. Shear bond strength testing (SBS) was performed, followed by statistical analysis of the results using one-way ANOVA (p 0.05). Results: After 21 days of thermocycling, AP and ZAS groups spontaneously debonded prior to testing. The remaining groups showed a decrease in mean shear bond strength between 11.7% and 58.5% after thermocycling, except the L/HFE group, which increased by 11.7%. L/HFE showed the highest bond strength at both test intervals, and at 21 days was significantly higher than that of the AP-S and L/APA-HFE groups, which in turn were higher than that of the L/APA group, which was higher than that of the SIE group (p 0.05). Conclusion: The etched, fired ceramic liner with silane treatment provided the strongest and most durable bond under the conditions tested. Alumina particle abrasion degraded the durability of the ceramic liner. Alumina particle abrasion, as-sintered zirconia, and SIE did not provide durable bond strengths. Keywords: zirconia, resin cement, shear bond strength