Purpose: To evaluate the relationship between biocompatibility and degree of monomer conversion of composites used to bond brackets to enamel, porcelain, resin, or metal surfaces at different time intervals. Materials and Methods: Twenty-four male Wistar rats were used, divided into 4 groups (n = 6) as follows: group C (control, polyethylene), group TCC (Transbond Color Change), group QC (Quick-Cure), and group EB (Eagle Bond). These substances were inserted into subcutaneous tissue. The events of inflammatory infiltrate, edema, necrosis, granulation tissue, multinuclear giant cells, young fibroblasts, and collagen formation were analyzed. The degree of conversion was evaluated by the Fourier method using infrared spectroscopy. Biocompatibility and degree of conversion were statistically analyzed using the Kruskal-Wallis and Dunn tests, and ANOVA and Tukey's test, respectively (p 0.05). Results: The composites caused a small amount of inflammatory infiltrate, edema, and granulation tissue at all experimental time intervals, showing a gradual reduction over time (p > 0.05). Group TCC showed the highest amount of fibroblasts and EB the smallest at the time interval of 15 days (p = 0.035). Group TCC showed the highest amount of collagen fibers and EB the smallest throughout the experiment; there was a significant difference in terms of collagen fibers between groups QC and EB, which differed from the control at 7 days (p = 0.006), and between groups EB and TCC (p = 0.018) at 30 days. Monomer conversion ranged from 64.1% in group EB at 7 days to 85.3% in group TCC at 30 days. Conclusion: Transbond Color Change composite showed a higher degree of conversion and a better healing process compared to Eagle Bond composite at 15 and 30 days. Quick-cure composite demonstrated a better degree of conversion and healing process than that of Eagle Bond, but this was not statistically significantly different. Keywords: composites, biocompatibility, adhesive dentistry