Objective: Assessment of the risk for tooth extraction in general and due to periodontal reasons in relation to patient factors. Method and Materials: All patients' charts of three German practices were screened for extractions until 300 patients with extractions (cases) had been collected. All patients without extractions that were screened served as controls. Cases and controls were compared regarding parameters at the patient level. Stepwise logistic regression analyses identified factors influencing the risk for extraction. Results: 2,174 patients were analyzed (300 cases/1,874 controls): aged 52.4/45.7 years (P .001), women 52%/57%, calcium channel blocker medication 15%/8% (P .001), mean Periodontal Screening Index (PSI) 2.5/1.8 (P .001). In the case group, 459 teeth were extracted. The risk for tooth extraction in general and due to periodontal reasons was associated with calcium channel blocker medication (OR 1.49/1.66), active smoking (1.35/1.59), age (10 years) (1.13/1.36), practice 1 (1.48/2.19), and number of sextants with PSI code 4 (1.33/1.78). A continuous dentition with >= 20 teeth left was protective against extractions in general. Conclusion: Calcium channel blocker medication, active smoking, age, individual dentists, and number of sextants with PSI code 4 are risk indicators for tooth extraction. Keywords: calcium channel blocker medication, periodontal disease, smoking, tooth extraction