This case report describes a patient with two missing teeth who underwent one-stage orthodontic treatment using minimally visible appliances. As one space was already closed, the treatment consisted of asymmetrical space closure using skeletal anchorage and a partial vestibular appliance. The goal was to close the extraction space by mesialising the posterior teeth while avoiding side-effects on the other teeth, considering that both the maxilla and mandible were symmetrical to each other, and the dental midlines were perfectly coincident. This case report demonstrates the possibility of achieving space closure using maximum anterior anchorage without adverse effects on the rest of the dentition and the profile. Keywords: asymmetrical space closure, maximum anterior anchorage, Miniscrew Assisted Palatal Appliance System