In recent years, numerous new dental materials have been introduced as alternatives to metal-ceramics for restorations on teeth and implants. This position paper presents the current evidence and respective clinical recommendations of the European Association for Osseointegration (EAO), one of the scientific partners of the International Journal of Prosthodontics, on material selection for single crowns (SCs) and multiple-unit implant-supported fixed dental prostheses (FDPs). Metal-ceramic restorations can be utilized in most clinical indications and are preferred to ceramic restorations in incidences such as long clinical implant crowns; cantilever implant restorations where one implant is supporting two crowns; implant-supported FDPs with extension units extending more than 7 to 8 mm (premolar size); implant-supported FDPs with more than two pontics; and implant-supported FDPs with small connector diameters due to limited intraocclusal space. Veneered or monolithic zirconia-ceramic and veneered or monolithic reinforced glass-ceramic implant-supported SCs are indicated for most SC cases in both the anterior and posterior areas. Today, implant-supported zirconia-ceramic FDPs that are conventionally veneered cannot be considered the material of first priority due to the pronounced risk for fracture of the framework and catastrophic fracture of the veneering material. Monolithic zirconia FDPs are a promising alternative to veneered implant-supported zirconia-ceramic FDPs. The mechanical stability of the translucent and shaded zirconia differs significantly between the grades of translucency. This must always be considered when clinical indications are recommended. As this specific area of prosthodontics is evolving fast, numerous studies evaluating different material options in implant prosthodontics are currently performed worldwide, and future consensus meetings will refine the present recommendations. The EAO will therefore regularly publish updated position papers on relevant topics.