This report presents a case of reconstructing and augmenting a buccal fenestration defect associated with simultaneous implant placement using recombinant human platelet-derived growth factor BB (rhPDGF-BB) combined with the synthetic alloplast beta-tricalcium phosphate (ß-TCP) and collagen membrane. Fenestration and fracture of the labial plate occurred at the time of implant placement at the maxillary left lateral incisor position. The sandwich bone augmentation technique was applied using autogenous bone as the inner grafting material and rhPDGF-BB + ß-TCP as the outer grafting material. A collagen barrier membrane was then tented over these materials. After approximately 5 months of healing, second-stage surgery was performed, showing complete healing at the defect site. This case suggests that the combination of rhPDGF-BB and ß-TCP can be a suitable material for predictable bone augmentation, especially during sandwich bone augmentation.