Purpose: Improvements in CAD/CAM have changed the methods of fabricating laminate veneers. The objective of this study was to evaluate the marginal and internal fit of ceramic veneers manufactured with different CAD/CAM techniques. Materials and Methods: A metal die was made by copying and scanning a prepared plastic maxillary right central incisor to design a laminate veneer. In total, 100 laminate veneers were made with four different CAD/CAM techniques (n = 25), including milled lithium disilicate (MLD), heat-pressed lithium disilicate (PLD) with 3D-printed wax patterns, milled zirconia (MZ), and 3D-printed zirconia (PZ). The virtual marginal and internal fit of fabricated veneers was evaluated with digital crown-fitting software. The actual marginal and internal fit was measured with the silicone replica method under a digital microscope. The measured data were analyzed using one-way ANOVA and Tukey tests. Results: There were significant differences in marginal and internal fit (P < .001) among manufacturing techniques. Both the virtual and actual marginal and internal gaps were higher in the PLD and PZ groups compared to the MLD and MZ groups. Conclusions: All four CAD/CAM techniques for manufacturing veneers—MLD, PLD with 3D printed wax patterns, MZ, and PZ—have clinically acceptable marginal and internal fit. MZ and MLD veneers demonstrated superior marginal and internal fit compared to PZ and PLD veneers with 3D-printed wax patterns.