This retrospective study aimed at evaluating the clinical outcomes of lithium disilicate prostheses onto

teeth and implants. A total of 860 restorations were delivered to 312 patients, including crowns,

veneers and onlays. Patients with uncontrolled gingival inflammation and/or periodontitis were

excluded, whilst subjects with occlusal parafunctions were included. The retrospective observational

period ranged between 13 to 17 years. The mechanical and esthetic performances of the restorations

were rated according to the modified CDA criteria. The recorded data were analyzed statistically. In

total, 26 mechanical complications were noticed: 17 ceramic chippings, 5 core fractures and 4 losses of

retention. Mechanical complications occurred predominantly in posterior areas; monolithic prostheses

showed the lowest percentage of structural problems. The clinical scores of layered and monolithic

restorations were fully satisfactory according to the modified CDA rating. The cumulative survival and

success rates ranged between 95.46-100% and 93.75-100% respectively up to 17 years of follow-up.

Although patient selection and the rigorous application of validated clinical protocols were considered

paramount, the use of lithium disilicate prostheses onto teeth and implants was reported to be a viable

and reliable treatment option in the long-term.