Histomorphometry of bone augmentations with Bio-Oss®: A systematic review and meta-analysis

To be able to properly evaluate the risk and the benefit of using commercially available bone substitutes, the material has to be tested both clinically and biologically. One of the main investigation criteria discussed in the literature is the new bone formation within human biopsies obtained at the time of implant placement. As new bone formation is regarded as a direct measure of osteoconductivity, leading to the osseointegration of the dental implant, it is directly related to the success of the implantation. Bio-Oss® has been evaluated in more than 500 Publications of which 45 present histological and histomorphometric data of human specimen. In 25 out of the 45 publication the individual data for each biopsy was reported and used to perform a meta-analysis. A total of 341 biopsies were included. The here presented data cover bone growth rates on Bio-Oss® in different indications and investigate the benefit of the addition of autogenous bone. Parole chiave: Bio-Oss, bone augmentation, meta-analysis