Myxomas of the maxillary sinus are uncommon benign tumors arising from the primitive mesenchyme. They may be related to dental malformations or missing teeth but may also occur without any abnormalities. They usually result in facial deformity manifested by slow, painless bony expansion. Although these tumors are well-circumscribed, they are more extensive than they appear due to their local aggressiveness and bone erosion. Therefore, it should be widely resected with maximal preservation of surrounding structures to prevent recurrence. This article reports a case of myxoma of the maxillary sinus and nighttime facial pain in a 33-year-old male who underwent curettage following debridement with a microdebrider via an intranasal endoscopic approach and surgery involving a modified Caldwell-Luc approach. Parole chiave: maxillary sinus, myxoma