Purpose: To evaluate the roughness and color stability of different types of resins used to immerse denture bases in various denture cleansers overnight. Materials and Methods: A total of 150 resin samples were made, which were divided into three groups of denture resins (conventional thermally activated, milled, and 3D printed; n = 50) and subdivided into five subgroups of denture cleaners (Distilled water, Corega tabs, Efferdent, NaOCl 1%, Listerine Cool Hint; n = 10). The roughness properties (Ra) and chromatic difference (ΔE00) were evaluated during 90 days and 180 days of overnight cleaning. Data were evaluated with two way ANOVA and Tukey tests for multiple comparisons (P < .05). Results: Listerine had significantly higher Ra and ΔE values (P < .001) compared to other solutions, which was significant in conventional resin at 180 days (P < .001). Conclusions: The use of Listerine as an overnight cleaner presents greater damage to the optical and surface properties of denture base resins, mainly with conventional resin, and 1% NaOCl is a valid option in relation to cost benefit.
