Advanced periodontal disease is often associated with severe loss of tooth support, necessitating prosthetic rehabilitation to restore function and esthetics. For tooth-supported restorations, periodontally compromised teeth may need to be extracted due to early failure from functional overload. For tooth/ implant-supported restorations, implants can be used to reduce the overload on teeth and to avoid tooth extraction, bone augmentation, or other risks associated with implant placement. The aim of this retrospective study was to evaluate the long-term outcomes of full-arch, retrievable, telescopic-retained prostheses (TRPs) on teeth and implants according to survival rate analyses and technical and biologic complications in full-mouth rehabilitation of periodontally compromised dentitions. A total of 18 periodontally compromised patients (7 women, 11 men) with a mean age of 46.8 years (SD: 6.3 years; range: 32 to 64 years) were selected to receive supplementary implants with the aim of extensive prosthetic support in combined tooth/implant TRPs and annually evaluated for technical and/or biologic failures/complications. After a followup period of 15 years, all prostheses were in function. Complication rates were low, and maintenance services were limited to minor interventions. Combined tooth/implant TRPs improve prosthetic support and offer successful function over the long term in patients with periodontally compromised dentition.