The purpose of this study was to evaluate the fracture resistance of computer-aided design/computer-assisted manufacture (CAD/CAM)-fabricated fiber-reinforced composite (FRC) denture retainers. Distal extension dentures incorporating two telescopic retainers and two molar pontics, with or without fiberglass, were fabricated by CAD/CAM or by the conventional polymerization method. The dentures were subjected to a vertical load on the second molar pontic until fracture. Within each manufacturing method, embedment of the FRC increased the mean final fracture load, suggesting the reinforcing effect of fiberglass. The polymerized dentures with FRC showed greater mean final fracture load than the CAD/CAM dentures with FRC.