Purpose: The aim of this retrospective study was to evaluate the 5-year clinical outcome for ceramic veneered cobalt-chromium (Co-Cr) fixed dental prostheses (FDPs) fitted in a private clinical setting. Materials and Methods: All patients treated consecutively with Co-Cr FDPs from January 2000 to November 2005 were included, and complications were registered. Patient records were examined for details on the restorations and abutment teeth. A total of 149 patients with 201 FDPs, 1,135 units, and 743 abutment teeth were recorded. Results: Of the 149 patients, 122 (82%) were followed for 5 years. Complications occurred in 34 patients (23%) and 38 FDPs (19%). The most frequent were caries (6.7% of patients, 5% of FDPs, 2.2% of abutments) and cement failure (6.7% of patients, 5% of FDPs, 3.1% of abutments). Cohesive ceramic fractures occurred in only 7 FDPs (3.5% of FDPs, 0.7% of units). No adhesive ceramic fractures were recorded. The 5-year cumulative rates for success and survival were 83.8% and 92.8%, respectively. Conclusions: Co-Cr FDPs appear to be a promising prosthodontic treatment modality, presenting low incidence of complications and a high survival rate during the first 5 years of function. However, long-term randomized controlled studies are necessary to confirm these findings.