A total of 163 monolithic restorations made from Vitablocs Mark II and luted adhesively or with resin cement were followed up for 3 to 70 months. Recall consisted of an evaluation of complete dental and hygiene status as well as quality assessment. Seven of 35 patients were lost to follow-up. Ninety-one percent of the 37 crowns, 23 partial crowns, and 89 inlays evaluated were in the posterior region. Combined survival estimate was 0.92 at the 48-month median observation time. Inlays and partial crowns performed well. Prevalence of complication and failure was highest for crowns (CP = 37.8%, FP = 21.6%). The results demonstrate that success relates to patient factors and restoration type, not luting protocol.