Purpose: This case series study evaluated the clinical outcomes of cantilevered veneerretained fixed partial dentures (VRFPDs) fabricated with IPS e.max Press for single-tooth replacement in the anterior arch. Materials and Methods: A total of 35 patients were treated with VRFPDs, including 17 cases in the maxilla and 18 in the mandible. The patients were evaluated at baseline and annually from October 2005 to July 2011 for the integrity of the VRFPDs, proximal contacts, occulsal relationships, pulp vitality, and tooth mobility. The degree of satisfaction was indicated with a visual analog scale. Results: During a mean observation time of 46.57 months, 35 VRFPDs on vital abutment teeth did not exhibit postoperative sensitivity or secondary caries. No fractures or chipping of the restorations occurred within the course of the evaluation. No patient complained of food impaction. One cantilevered pontic needed adjustment on the incisal edge due to premature contacts after the 3-year recall examination. Conclusion: Cantilevered IPS e.max Press VRFPDs should be considered a minimally invasive, single-tooth restorative strategy in the anterior or first premolar area. Longer observation periods are necessary before this type of restorative design can be recommended as a general conservative procedure.