The aim of this study was to evaluate the effect of the spray pattern, water flow rate, and cutting position on the cutting efficiency of high-speed dental handpieces. One- and three-port high-speed handpieces were selected. Cutting efficiency (mm/s) in different cutting positions was evaluated in vitro on machinable ceramic underwater flow rates of 15, 25, and 35 mL/min. Statistical analysis revealed significant differences in cutting efficiency for the various cutting positions and flow rates. The authors recommend multiport handpieces with a flow rate greater than 30 mL/min for use in clinical practice, especially during groove cutting.