The aim of this prospective clinical study was to investigate the long-term survival of Procera AllCeram all-ceramic crowns in the anterior and posterior regions. Between 1997 and 2005, 155 Procera crowns with aluminum oxide cores were placed in 50 patients. Patients were recalled in 2005 for a clinical assessment. Thirty-nine patients with 135 crowns attended the recall examination. Of the 135 total crowns, 103 were located in the posterior region and 32 were located in the anterior region. The cumulative survival rate was 100% in the anterior region and 98.8% in the posterior region (1 crown fracture) after 5 and 7 years. Clinical success was achieved irrespective of the tooth position, cement used (resin composite or glass-ionomer cement), or the core design with reduced or conventional margins. Procera AllCeram seems to be a predictable technique for esthetic all-ceramic single crown restorations in the anterior and posterior regions.