The biologically oriented preparation technique (BOPT) has revolutionized the execution of fixed prosthetic treatments, ensuring tissue stability and the integration of the gingival tissue with the prosthetic restorations. BOPT follows both a clinical and laboratory sequence; the two must be perfectly integrated and synchronized, with the phase of preparation and temporary restorations in the clinic correlating with a well-founded and protocolized execution of the laboratory steps. In turn, prosthetic work returned to the clinic must show perfect integration between the prosthesis, the preparation, and the periodontal tissue, with a balance between pink and white esthetics. The clinical case in the present article illustrates the close relationship between the clinical and laboratory steps, including the technical laboratory procedures, that make it possible to achieve these objectives. The aim of the article is to introduce the concept of the prosthetic adaptation profile of new restorations, establishing the definition, importance, and direct relationship of this profile with the success of the rehabilitation treatment.