Osseous resective surgery has been widely advocated in the treatment of periodontitis. The treatment traditionally has been done with rotary and manual instruments, but piezoelectric devices recently have also been used. A total of 20 adult patients diagnosed with moderate to severe chronic periodontitis were selected. A split-mouth study design was conducted such that one sextant was operated using piezoelectric bone surgery (test) and one with traditional instruments (control) in two separate sessions. Patients were asked to evaluate their perception of cold sensitivity, spontaneous pain, bleeding, swelling, and chewing discomfort. Piezoelectric bone surgery seems to be tolerated slightly better than conventional rotary instruments.